{"id":932,"date":"2026-01-31T21:02:27","date_gmt":"2026-01-31T20:02:27","guid":{"rendered":"https:\/\/www.aldichdesign.com\/portafolios\/3-claves-del-avance-historico-que-podria-cambiar-el-tratamiento-del-cancer-de-pancreas\/"},"modified":"2026-01-31T21:02:27","modified_gmt":"2026-01-31T20:02:27","slug":"3-claves-del-avance-historico-que-podria-cambiar-el-tratamiento-del-cancer-de-pancreas","status":"publish","type":"portafolios","link":"https:\/\/www.aldichdesign.com\/en\/portafolios\/3-claves-del-avance-historico-que-podria-cambiar-el-tratamiento-del-cancer-de-pancreas\/","title":{"rendered":"3 claves del avance hist\u00f3rico que podr\u00eda cambiar el tratamiento del c\u00e1ncer de p\u00e1ncreas"},"content":{"rendered":"

Esta infograf\u00eda cient\u00edfica representa uno de los avances m\u00e1s relevantes de los \u00faltimos a\u00f1os en la investigaci\u00f3n del c\u00e1ncer de p\u00e1ncreas: una estrategia de triple ataque terap\u00e9utico<\/strong> capaz de eliminar tumores en modelos precl\u00ednicos sin que aparezcan resistencias.<\/p>\n

La pieza ha sido dise\u00f1ada para explicar de forma visual y estructurada c\u00f3mo el bloqueo simult\u00e1neo de KRAS, EGFR y STAT3 impide que las c\u00e9lulas tumorales activen v\u00edas de escape<\/strong>. A trav\u00e9s de esquemas jerarquizados, ampliaciones moleculares y una narrativa visual clara, la infograf\u00eda gu\u00eda al lector desde el origen gen\u00e9tico del tumor hasta el impacto final de la terapia combinada. <\/p>\n

El dise\u00f1o pone especial \u00e9nfasis en uno de los grandes retos de este tipo de c\u00e1ncer: la capacidad del tumor para adaptarse a los tratamientos convencionales. Visualmente, este concepto se traduce en la representaci\u00f3n de las distintas rutas moleculares que sostienen la supervivencia tumoral y en c\u00f3mo su bloqueo coordinado conduce a la regresi\u00f3n completa del tumor. <\/p>\n

\"Infograf\u00eda<\/p>\n

 <\/p>\n

Contexto cient\u00edfico del avance<\/h3>\n

El estudio<\/a> representado en la infograf\u00eda ha sido liderado por el Dr. Mariano Barbacid<\/span><\/span> y su grupo de investigaci\u00f3n en el Centro Nacional de Investigaciones Oncol\u00f3gicas<\/span><\/span> (CNIO)<\/strong>. El c\u00e1ncer de p\u00e1ncreas es uno de los tumores m\u00e1s agresivos, con una mortalidad cercana al 95 %, en gran parte debido a su diagn\u00f3stico tard\u00edo y a la r\u00e1pida aparici\u00f3n de resistencias terap\u00e9uticas. <\/p>\n

Cerca del 90 % de estos tumores se inician por mutaciones en el oncog\u00e9n KRAS<\/strong>, que act\u00faa como motor principal del crecimiento tumoral. Aunque existen inhibidores dirigidos contra KRAS y EGFR, las c\u00e9lulas tumorales activan una tercera v\u00eda de escape mediada por STAT3<\/strong>, que les permite sobrevivir y adaptarse al estr\u00e9s terap\u00e9utico. <\/p>\n

La estrategia desarrollada por el equipo del CNIO combina f\u00e1rmacos dirigidos contra KRAS, EGFR y STAT3<\/strong>, logrando cerrar simult\u00e1neamente estas rutas cr\u00edticas. En modelos precl\u00ednicos, incluidos tumores humanos implantados en ratones inmunodeprimidos (PDX), esta triple terapia provoc\u00f3 la eliminaci\u00f3n completa del tumor, evit\u00f3 reca\u00eddas a largo plazo y no mostr\u00f3 toxicidad relevante. <\/p>\n

\"\"<\/p>\n

Grupo de Oncolog\u00eda Molecular del CNIO, liderado por el Dr. Mariano Barbacid<\/span><\/span>. Fuente: CNIO <\/p>\n

Dise\u00f1o cient\u00edfico como herramienta de comunicaci\u00f3n<\/h3>\n

Esta infograf\u00eda refleja mi enfoque como bioqu\u00edmica e ilustradora cient\u00edfica: utilizar el dise\u00f1o para hacer comprensibles mecanismos biol\u00f3gicos complejos<\/strong>, manteniendo el rigor cient\u00edfico y facilitando la transferencia del conocimiento m\u00e1s all\u00e1 del laboratorio.<\/p>\n

El objetivo no es sustituir la investigaci\u00f3n, sino acompa\u00f1arla y amplificar su impacto<\/strong>, transformando resultados altamente t\u00e9cnicos en una herramienta visual clara, accesible y efectiva.<\/p>\n","protected":false},"featured_media":888,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"tipologia":[24],"class_list":["post-932","portafolios","type-portafolios","status-publish","has-post-thumbnail","hentry","tipologia-infographic"],"_links":{"self":[{"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/portafolios\/932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/portafolios"}],"about":[{"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/types\/portafolios"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/media\/888"}],"wp:attachment":[{"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/media?parent=932"}],"wp:term":[{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/www.aldichdesign.com\/en\/wp-json\/wp\/v2\/tipologia?post=932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}